从协同作用到耐药性:在肝细胞癌中导航索拉费尼布和铁死之间的复杂关系
Zijian Wang1, Chunyang Zhou2, Yiming Zhang3
1College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|December 26, 2023
概括
肝细胞癌 (HCC) 用索拉菲尼布治疗受到药物耐药性的阻碍. 本综述探讨了细胞死亡途径铁亡如何影响肝癌中索拉芬尼的疗效和耐药性.
科学领域:
- 在瘤学瘤学.
- 生物化学 生物化学
- 细胞生物学 细胞生物学
背景情况:
- 肝细胞癌 (HCC) 是一个重要的全球健康问题.
- 索拉费尼布是先进的HCC的第一线治疗,但患者的反应有所不同,药物耐药性是常见的.
- 铁,一种依赖于铁的细胞死亡,在治疗HCC的索拉菲尼布治疗中起着复杂的作用.
研究的目的:
- 在HCC中全面审查铁和索拉费尼布之间的关系.
- 阐明铁灭菌如何影响索拉费尼布的疗效和耐药性.
- 提出针对铁亡的新型治疗策略,以克服索拉费尼布耐药性.
主要方法:
- 关于HCC中ferroptosis和sorafenib最近研究的文献综述.
- 分析ferroptosis影响索拉费尼布反应的机制.
- 综合发现,以确定治疗机会.
主要成果:
- 铁灭诱导可以增强索拉费尼布在HCC中的抗癌作用.
- 相反,铁亡也可能导致 sorafenib 耐药性的发展.
- 铁死在索拉费尼布治疗中的确切作用是复杂的,并且取决于背景.
结论:
- 向铁亡是一种有前途的策略,可以克服HCC中索拉芬尼抗性.
- 需要进一步的研究,以充分理解和利用铁 - 索拉费尼布的相互作用,以改善肝癌治疗.
- 开发调节铁亡的治疗方法可以提高索拉费尼布的疗效和患者的治疗结果.
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