电子烟是否会增加感染SARS-CoV-2的可能性? 矛盾的是,是的和没有
Rattapol Phandthong1, Man Wong1, Ann Song1
1Department of Molecular, Cell and Systems Biology, University of California, Riverside, California, United States.
电子烟气溶会影响SARS-CoV-2感染的易感性. 烯基醇/植物甘油和尼古丁增强了感染,而JUUL气溶中的酸提供了保护. 特定的成分决定了电子烟对病毒感染风险的影响.
科学领域:
- 病毒学和呼吸道细胞生物学
- 电子烟气溶的毒理学
背景情况:
- 关于电子烟 (EC) 与SARS-CoV-2感染之间的关系的数据有限且相互矛盾.
- 了解EC气溶成分对病毒易感性的影响对于公共卫生至关重要.
研究的目的:
- 研究电子烟气溶如何影响人类支气管上皮细胞中的SARS-CoV-2感染.
- 为了确定EC气溶中负责改变感染易感性的特定化学成分.
主要方法:
- 人类支气管上皮组织 (hBETs) 暴露于来自JUUL和BLU ECs的气溶,以及单个成分 (尼古丁,甘醇 (PG),植物甘油 (VG),酸).
- 暴露发生在空气-液体界面 (ALI),随后对SARS-CoV-2伪粒子感染进行了评估.
- 评估了包括内细胞和蛋白酶活性 (TMPRSS2) 在内的机制,以及pH值变化.
主要成果:
- 来自PG/VG,含尼古丁的PG/VG和BLU EC的气溶增加了SARS-CoV-2伪粒子感染.
- 与对照组相比,JUUL EC气溶并没有显著增加感染.
- 尼古丁和PG/VG通过增加内细胞酶或提高pH导致更高的TMPRSS2活性,增强了感染,而JUUL气溶中的酸减轻了感染.
结论:
- 电子烟气溶成分对SARS-CoV-2感染的易感性有不同的影响.
- 烯基醇/植物甘油和尼古丁可以增强病毒的进入,而酸则表现出保护作用.
- 在确定它们对病毒感染风险的影响方面,EC气溶的特定成分至关重要.
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