在与男性发生性关系的男性中,暴露前预防的坚持:系统审查和元分析
Suchitra Hudrudchai1,2, Charin Suwanwong2, Pitchada Prasittichok2
1Faculty of Nursing, Rajamangala University of Technology Thanyaburi, Pathum Thani, Thailand.
Journal of preventive medicine and public health = Yebang Uihakhoe chi
|December 26, 2023
概括
高等教育,更多的性伴侣和艾滋病毒阳性伴侣与与男性发生性关系 (MSM) 的男性更好地遵守暴露前预防 (PrEP) 有关. 药物使用和抑郁症与较低的坚持有关.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 预防传染病 预防传染病
背景情况:
- 暴露前预防 (PrEP) 是预防人类免疫缺陷病毒 (HIV) 传播的关键策略.
- 与男性发生性关系的男性 (MSM),特别是高风险群体,广泛采用和坚持PrEP的有效性至关重要.
- 了解影响PrEP遵守的因素对于有针对性的干预至关重要.
研究的目的:
- 对现有证据对与MSM中PrEP遵守相关的因素进行元分析.
- 为了确定影响PrEP在这个人群中的坚持人口统计学,行为,物质使用和心理社会因素.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 在PubMed,ScienceDirect和Scopus的文献中搜索2018年1月至2022年12月期间发表的研究.
- 包括报告MSM中PrEP坚持比例的研究,使用纽卡斯尔-太华尺度进行质量评估.
主要成果:
- 从最初的268项研究中,包括了12项研究.
- 与更高 PrEP 坚持相关的因素包括高等教育 (OR,1.64),更多的性伴侣 (OR,1.16) 和与艾滋病毒阳性伴侣发生性关系 (OR,1.59).
- 药物使用 (OR,0.83) 和较低的抑郁水平 (OR,0.55) 也与prep坚持有关.
结论:
- 几个因素影响 PrEP 在MSM 中的坚持,包括教育程度,性网络特征和心理健康状况.
- 调查结果可以为开发改善PrEP遵守的干预措施提供信息.
- 需要进一步的研究,以更全面地了解 PrEP 在MSM 群体中的坚持.
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