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光神经头部区域的纤维有限元素建模

Mohammad R Islam¹, Fengting Ji², Manik Bansal³

¹Department of Ophthalmology, University of Pittsburgh, Pittsburgh PA, USA; Department of Mechanical Engineering, University of Texas Rio Grande Valley, Edinburg TX, USA.

Acta biomaterialia

|December 26, 2023

概括

视神经头部 (ONH) 的新纤维有限元素模型准确模拟了它的生物力学. 该模型揭示了原纤维结构如何影响ONH功能和视力丧失,进步了我们对眼睛生理学的理解.

科学领域:

眼睛的生物力学
计算建模计算建模
结合性组织结构结合性组织结构

背景情况:

视神经头部 (ONH) 对于视力至关重要,并依赖于复杂的原纤维结构.
现有的计算模型往往简化了ONH的纤维性质,限制了生物力学见解.
了解ONH生物力学对于诊断和治疗视力损失条件至关重要.

研究的目的:

开发一个高保真纤维有限元素 (FFE) 模型的ONH.
将基于组织学的3D原纤维组织纳入ONH模型.
研究纤维结构在ONH生物力学和菌株传播中的作用.

主要方法:

使用猪ONH的偏光显微镜数据构建了一个FFE模型.
代表了离散的原纤维束与梁元素和通道组织作为连续结构.
模仿组织纤维的方向,宽度分布和组织间的连续性.

主要成果:

FFE模型准确地预测了在实验性通货膨胀测试中观察到的非线性ONH反应.
该模型捕获了微结构机制,如纤维相互作用和长距离应变传输.
结果与实验数据一致,并为纤维组织力学提供了新的见解.

结论:

FFE模型有助于理解原纤维结构如何决定ONH生物力学.
这种模型可以阐明ONH中生物机械损伤的微观结构基础.
它提供了一种工具来研究原重塑在诸如玻璃眼等疾病中的效果.

关键词:

生物力学生物力学原蛋白是一种原蛋白.眼睛眼睛眼睛眼睛纤维纤维是一种纤维.有限元素建模的模型.视神经的头部视神经的头部斯克莱拉拉 (Sclera) 是一个

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