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系统性硬化症中的纤维细胞亚群:个体亚群的功能影响和与临床特征的相关性

Honglin Zhu¹, Hui Luo², Brian Skaug³

¹Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, China; Department of Internal Medicine 3, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.

The Journal of investigative dermatology

|December 26, 2023

概括

系统性硬化症 (SSc) 涉及皮肤中纤维细胞亚群的不平衡,导致纤维化进展. 针对特定的纤维细胞类型可能提供新的SSc治疗策略.

科学领域:

免疫学免疫学免疫学
皮肤病学皮肤病学
基因组学就是基因组学.

背景情况:

纤维细胞是组织平衡和疾病中的关键细胞.
系统性硬化症 (SSc) 是一种复杂的纤维性疾病,细胞机制尚不清楚.
了解纤维细胞异质性对于SSc的发病过程至关重要.

研究的目的:

研究个体纤维细胞群在全身性硬化症 (SSc) 中的作用.
为了确定与SSc皮肤纤维化相关的特定纤维细胞特征.
探索针对纤维细胞亚种群进行SSc治疗的潜力.

主要方法:

单细胞RNA测序,大量RNA测序和临床数据的综合分析.
纤维细胞群变化的多色免疫光验证.
机器学习模型评估纤维细胞特征的预测价值.

主要成果:

在SSc皮肤中,COMP+,COL11A1+,MYOC+,CCL19+,SFRP4/SFRP2+和PRSS23/SFRP2+纤维细胞特征的增加.
在SSc中观察到CXCL12+和PI16+纤维细胞特征的降低.
亲纤维细胞和亲炎性纤维细胞的特征与纤维化严重程度相关.
纤维细胞特征使用机器学习改进了SSc纤维化进展的分类.

结论:

纤维细胞亚种群的不平衡显著导致SSc皮肤纤维化.
特定的纤维细胞群 (例如,COMP+,COL11A1+) 是SSc的关键驱动因素.
准与疾病相关的纤维细胞种群为SSc和其他纤维状况提供了一个有前途的治疗途径.

关键词:

皮肤纤维化皮肤纤维化疾病的结果.纤维细胞细胞.这就是为什么SSc SSc 亚种群亚种群亚种群

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