免疫-金氨酸通路在耐治疗精神分裂症中的作用
Wenjin Chen1, Yichang Tian2, Mengzhuang Gou1
1Peking University HuiLongGuan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, China.
Progress in neuro-psychopharmacology & biological psychiatry
|December 26, 2023
概括
耐治疗精神分裂症 (TRS) 涉及到一个不平衡的免疫-炎症反应系统 (IRS) 和 kynurenine 途径 (KP). 较高的IRS/CIRS比率和改变的KP代谢,特别是QUIN/KYNA比率,与TRS有关,这表明它在神经毒性中发挥了作用.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
背景情况:
- 免疫-炎症反应系统 (IRS) 和 kynurenine 途径 (KP) 与精神分裂症病理生理学有关.
- 炎症会影响精神分裂症患者的KP代谢.
- 这项研究研究了KP代谢物,IRS和治疗耐药精神分裂症 (TRS) 中的补偿性免疫调节反射系统 (CIRS).
研究的目的:
- 在TRS患者中调查KP代谢物,IRS和CIRS之间的关系.
- 确定与TRS相关的风险因素.
- 探索免疫标记物和KP代谢之间的相互作用,用于预测TRS.
主要方法:
- 量化血细胞因子用于计算TRS患者 (n=53),没有TRS患者 (n=47) 和健康对照患者 (HCs,n=49) 的IRS/CIRS比率.
- 测量的血清KP代谢物:金氨酸 (KYN),金氨酸 (KYNA) 和氨酸 (QUIN).
- 分析了QUIN/KYNA比率及其与IRS/CIRS的相互作用,用后勤回归来预测TRS.
主要成果:
- 与非TRS患者和HCs相比,TRS患者的IRS/CIRS比率显著更高.
- 在TRS患者中,KYN和KYNA水平明显低于HC患者.
- 较高的IRS/CIRS比率和较年轻的发病年龄是TRS的风险因素. 昆/基纳比率调节了IRS/CIRS和TRS之间的关联.
结论:
- 在TRS中,外周免疫反应失衡,有利于IRS,并可能导致神经毒性.
- 在TRS中,外周KP激活也失衡,KYN和KYNA水平降低.
- 在预测TRS方面,IRS/CIRS和QUIN/KYNA比率之间的相互作用是显著的,这表明在TRS病变发生过程中,免疫-kynurenine通路的作用.
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