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Updated: Jul 7, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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灵活的蛋白质-蛋白质对接与多轨代变压器

Lee-Shin Chu1, Jeffrey A Ruffolo2, Ameya Harmalkar1

  • 1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, USA.

Protein science : a publication of the Protein Society
|December 26, 2023
PubMed
概括

GeoDock是一种新的深度学习方法,比传统方法更快地预测蛋白质-蛋白质对接结构. 它允许在结合过程中进行构造变化,提高复杂结构预测和虚拟选的准确性.

关键词:
深度学习是一种深度学习.灵活的蛋白质对接蛋白质与蛋白质的相互作用

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Protein Translocation Machinery on the ER Membrane

The translocon complex situated on the ER membrane is the main gateway for the protein secretory pathway. It facilitates the transport of nascent peptides into the ER lumen and their insertion into the ER membrane.
Sec61 protein conducting channel
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Multi-pass Transmembrane Proteins and β-barrels

In multi-pass transmembrane proteins, the polypeptide chain crosses the membrane more than once. The transmembrane polypeptide chain either forms an α-helix or β-strand structure. α-Helix containing multi-pass transmembrane proteins are ubiquitous, whereas β-strand containing ones are mainly found in gram-negative bacteria, mitochondria, and chloroplasts.
α-Helix containing multi-pass transmembrane proteins
Multi-pass transmembrane proteins such as...
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