益生菌Bacillus cereus GM对实验性曼索尼杆菌菌的作用
Victor Hugo Barbosa Dos Santos1,2, Eulália Camelo Pessoa de Azevedo Ximenes2,3, Renan Andrade Fernandes de Souza1,2
1Instituto Keizo Asami (iLIKA), Universidade Federal de Pernambuco, Recife, PE, Brazil.
Parasitology research
|December 26, 2023
概括
转基因谷菌,一种益生菌,显著降低了小鼠中的Schistosoma mansoni虫负担和肝卵数量. 在感染之前的早期管理在减轻寄生虫负载和炎症方面产生了最好的结果.
科学领域:
- 免疫学 免疫学 免疫学
- 寄生虫学的寄生虫学
- 微生物学 微生物学
背景情况:
- 益生菌增强肠道粘膜的完整性,并对抗由虫等病原体引起的失生症.
- 甲状腺,一种寄生虫疾病,构成了全球健康的重大挑战,需要新的治疗策略.
研究的目的:
- 为了评估Bacillus cereus转基因子在杆菌病的实验模型中的疗效.
- 评估Bacillus cereus GM对寄生虫负担,肝功能和 Schistosoma mansoni 感染小鼠的炎症反应的影响.
主要方法:
- 在不同的时间点 (早期和晚期感染) 给感染了Schistosoma mansoni的小鼠注射了Bacillus cereus GM子.
- 分析了寄生虫负载 (虫,蛋),肝酶 (AST,ALT,ALP),颗粒瘤大小和细胞因子 (Th1,IL-17,IL-4) 的情况.
主要成果:
- 早期使用Bacillus cereus GM (G2) 导致总虫 (43.4%),雌性虫 (48.8%) 和肝卵 (42.5%) 的数量显著减少.
- 早期 (G2) 和晚期 (G3) 两种药物都减少了肝脏和肠道中的颗粒瘤体积,并调节了Th1和IL-17细胞因子概况.
- 细菌花转基因改善了某些肝功能标志物,包括AST和ALP水平,特别是在早期服用时.
结论:
- 细菌花转基因表明,在减少小鼠的schistosoma mansoni感染负担和相关病理方面具有显著的潜力.
- 早期使用Bacillus cereus GM在控制寄生虫负载和减轻炎症反应方面更有效.
- 细菌花转基因调节宿主免疫反应,提供了一个有前途的益生菌为基础的方法,用于杆菌病的管理.
关键词:
细菌花类植物 (Bacillus cereus) 是一种免疫调节是一种免疫调节.益生菌是一种益生菌.这种病原体是Schistosoma mansoni.这种疾病叫做schistosomiasis.更多相关视频
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