在Sjögren病患者中,Xerostomia库存的最小重要差异是Sjögren病患者
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Zainab Assy1, William Murray Thomson2, Henk S Brand1
1Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands.
Oral diseases
|December 26, 2023
概括
在Sjögren中 Xerostomia库存 (XI) 的最小重要差异 (MID).
科学领域:
- 口腔医学是指口腔医学.
- 类风湿病学 类风湿病学
- 临床试验 临床试验
背景情况:
- Xerostomia (口腔干燥) 显著影响Sjögren综合征 (SjD) 患者的生活质量.
- Xerostomia Inventory (XI) 是一个常见的患者报告的口腔干燥的结果测量方法.
- 对 XI 定义的最小重要差异 (MID) 对于解释临床试验结果至关重要.
研究的目的:
- 为了确定SjD患者口腔干燥的XI的MID.
- 建立临床相关改善异口症症状的基准.
主要方法:
- 这是一项前性研究,涉及34名SjD患者接受尾镜检查,以及15名SjD患者在对照组.
- 在干预后的多个时间点收集了XI分数.
- 使用改善和没有改善的患者之间的XI分数的平均差异来计算MID.
主要成果:
- 在对照组中没有观察到显著的XI分数变化.
- 在XI得分下降四个点,表明在sialendoscopy组的短期临床相关改善.
- 长期的临床相关改善 (≥16周) 需要XI得分减少7个点.
结论:
- 在XI上4点的MID表示SjD患者的短期临床相关改善.
- 在XI上7点的MID表明长期的临床相关改善.
- 建立XI的MID有助于在未来的研究中评估异口腔治疗的疗效.
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