[寄生虫衍生非编码RNA的跨物种调节和潜在机制:一篇评论]
1Guangxi University of Chinese Medicine; Guangxi Key Laboratory of Translational Medicine for Treating High-Incidence Infectious Diseases with Integrative Medicine, Nanning, Guangxi 530200, China.
概括
寄生虫衍生的非编码RNAs (ncRNAs),包括microRNAs (miRNAs),长非编码RNAs (lncRNAs) 和圆形RNAs (circRNAs),可以与宿主细胞形成调节网络. 这些ncRNAs影响宿主基因表达,并有助于寄生虫感染和病原性.
科学领域:
- 分子生物学分子生物学
- 寄生虫学的寄生虫学
- 基因组学就是基因组学.
背景情况:
- 寄生虫感染涉及寄生虫和宿主之间的复杂相互作用.
- 非编码RNAs (ncRNAs) 在生物过程中起着至关重要的作用.
- 细胞外囊泡调解细胞间通信,包括ncRNAs的转移.
研究的目的:
- 提供对表征寄生虫衍生的ncRNAs方法的概述.
- 探索寄生虫衍生的ncRNAs在宿主基因表达中的跨物种调节作用.
- 阐明寄生虫ncRNA与宿主相互作用背后的机制.
主要方法:
- 对寄生虫ncRNA识别和表征的当前文献的综述.
- 对研究寄生虫衍生的ncRNAs在宿主细胞中的功能进行分析.
- 检查通过细胞外囊泡进行ncRNA转移和作用的拟议机制.
主要成果:
- 寄生虫ncRNAs,包括miRNAs,lncRNAs和circRNAs,可以在宿主环境中检测到.
- 这些ncRNA可以与宿主miRNA和信使RNA (mRNA) 形成具有竞争力的内源RNA (ceRNA) 网络.
- 寄生虫ncRNAs有助于宿主-寄生虫相互作用,感染和病变发生.
结论:
- 鉴定寄生虫ncRNA的特征对于理解宿主-病原体相互作用至关重要.
- 寄生虫ncRNAs代表治疗干预的潜在目标.
- 需要进一步的研究,以充分阐明ncRNA介导的跨物种调节机制.
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