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接种疫苗的时间不会影响总抗SARS-CoV-2抗体反应

Laura Pighi¹, Simone De Nitto¹, Gian Luca Salvagno¹

¹Section of Clinical Biochemistry and School of Medicine, University of Verona, Verona, Italy.

Chronobiology international

|December 27, 2023

概括

接种疫苗的时间不会影响COVID-19抗体水平. 这项研究发现,无论注射时间如何,在Comirnaty疫苗接种后,抗SARS-CoV-2抗体总数没有显著差异.

科学领域:

免疫学免疫学免疫学
疫苗学疫苗学疫苗学
公共卫生公共卫生

背景情况:

由于SARS-CoV-2大流行,需要快速开发和部署疫苗.
了解影响疫苗免疫性因素对于优化公共卫生战略至关重要.
像Comirnaty这样的mRNA疫苗已显示出高效,但其免疫性可能受到各种因素的影响.

研究的目的:

调查一天中基于mRNA的COVID-19疫苗接种的时间是否会影响抗SARS-CoV-2受体结合域 (RBD) 抗体的水平.
为了确定疫苗接种时间是否会影响对科米纳蒂疫苗的免疫反应.

主要方法:

一组249名医疗保健工作者接受了科米拉蒂疫苗的第一剂.
测量了总的抗SARS-CoV-2 RBD抗体.
在不同疫苗接种时间点的抗体水平在一天中进行了比较.

主要成果:

不同的疫苗接种时间之间没有观察到总抗SARS-CoV-2抗体水平的统计学上显著差异.
疫苗注射的时间没有引起显著不同的免疫反应 (p > 0.05).

结论:

基于mRNA的初级COVID-19疫苗接种的日间时间似乎没有影响抗SARS-CoV-2总抗体水平.
这些发现表明,疫苗接种时间表可以灵活安排,而不会影响抗体反应.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.疫苗接种疫苗接种抗体是对抗体的重要组成部分.昼夜节律昼夜节律

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