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Updated: Jun 22, 2026

Introducing a Gene Knockout Directly Into the Amastigote Stage of Trypanosoma cruzi Using the CRISPR/Cas9 System
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安德罗格拉福利德:来自Cymbopogon schoenanthus的Diterpenoid被确定为一种新的打击Trypanosoma cruzi的化合物,使用机器学习和实验方法

Henrique Barbosa1, Gabriel Zarzana Espinoza2, Maiara Amaral3

  • 1Center for Natural and Human Sciences, Federal University of ABC, São Paulo 09210-180, Brazil.

Journal of chemical information and modeling
|December 27, 2023
PubMed
概括

机器学习模型确定了来自植物的andrographolide作为治疗查加斯病 (美国三虫病) 的有前途的天然产品. 这种化合物对寄生虫Trypanosoma cruzi具有显著的活性,对哺乳动物细胞的毒性较低.

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