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细胞损失导致微血管重塑和鼻多的形成

Na Cui¹, Xuewei Zhu¹, Chen Zhao¹

¹Department of Otorhinolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.

Acta oto-laryngologica

|December 27, 2023

概括

慢性鼻多性鼻炎 (CRSwNP) 中的细胞损失与血管透性增加和水有关. 这种功能障碍有助于多体的形成,特别是在异敏性CRSwNP中.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
免疫学免疫学免疫学
血管生物学血管生物学

背景情况:

慢性鼻炎 (CRS) 与血管透性增加和炎症细胞泄漏有关.
了解CRS中组织和微血管功能障碍的机制至关重要.

研究的目的:

调查皮质细胞在组织,微血管功能障碍和CRS与鼻息肉 (CRSwNP) 的血管重塑中的作用.
为了区分这些机制之间的eosinophilic CRSwNP (eCRSwNP) 和非eosinophilic CRSwNP (非eCRSwNP).

主要方法:

收集了63个组织样本:42个CRSwNP (22个eCRSwNP,20个非eCRSwNP) 和21个没有鼻息肉的CRSsNP).
利用免疫光学量化微血管密度 (MVD) 和微血管细胞覆盖率指数 (MPI).

主要成果:

在CcRSwNP中观察到显著增加的白蛋白表达和减少的MPI.
在MPI和血白蛋白水平之间,以及MPI和乙氨基酸细胞数量之间发现了负相关性.
与对照组相比,CcRSwNP组中IL-4,Ang-1和Ang-2的表达增加.

结论:

在eCRSwNP中发生的细胞损失可能导致微血管功能障碍,间歇性胀和eosinophilic泄漏.
这些与细胞相关的变化与鼻的发展和维持有关.

关键词:

慢性鼻炎是什么意思慢性鼻炎 edemema edem 胀胀胀在胀胀埃索诺菲尔透的透方式微容器密度密度微容器密度微容器细胞覆盖率指数鼻腔多重体是指鼻腔多重体.

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