尿病原体及其抗菌素耐药模式在尼泊尔东部怀疑尿路感染的患者中:一项基于住院患者的医院研究
Bikash Kumar Sah1, Prasanna Dahal1, Shyam Kumar Mallik1
1Purbanchal University School of Health Sciences, Purbanchal University, Gothgaun, Morang, Nepal.
SAGE open medicine
|December 27, 2023
概括
尿路感染 (UTI) 很常见,大肠杆菌是主要的原因. 胆固醇显示对抗耐药细菌的有效性,突出了需要更好的抗菌药物管理的需要.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 临床药房 临床药房
背景情况:
- 尿路感染 (UTI) 是全球主要的发病和死亡原因,特别是在患有并发症的患者中.
- 尿道感染在全球范围内对住院患者的贡献很大.
研究的目的:
- 为了识别导致尿路感染的常见细菌尿病原体.
- 确定这些尿病原体的抗微生物敏感性模式,包括多耐药 (MDR) 和广泛耐药 (XDR) 菌株.
主要方法:
- 在尼泊尔Koshi医院对住院患者进行了一项描述性的横截面研究,这些患者怀疑患有尿路感染.
- 使用标准实验室程序和临床和实验室标准研究所 (CLSI) 的指导方针进行了细菌鉴定和抗微生物敏感性测试.
- 使用统计分析来确定显著的关联,p值<0.05被认为是显著的.
主要成果:
- 在305个尿样中,251个 (82.29%) 显示出显著的细菌生长.
- 大肠杆菌是最常见的尿路病原体 (62.94%),其次是Klebsiella肺炎 (12.35%).
- 科里斯显示出100%的对格拉姆阴性尿病原体的敏感性. 大肠杆菌是最常见的耐药细菌 (70%).
- MDR/XDR尿病原体与糖尿病有显著的关联;糖尿病患者患尿病原体的几率翻了一番.
结论:
- 大肠杆菌和Klebsiella pneumoniae是尿路感染中最常见的尿病原体.
- 胆固醇对MDR和XDR尿病原体有效.
- 优化的抗菌药物管理计划对于各种医疗保健机构有效的尿路感染管理至关重要.
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