肺部超声波的体积状况评估在末期脏疾病:一个系统的审查
Aileen Kharat1, Faissal Tallaa2, Marc-Antoine Lepage3
1Division of Respirology, Geneva University Hospitals, Switzerland.
Canadian journal of kidney health and disease
|December 27, 2023
概括
肺部超声波有效地识别了透析患者的亚临床体积过载. 然而,目前的试验显示,与标准护理相比,死亡率或心血管事件没有改善,尽管降低了血压.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 关键护理医学 关键护理医学
背景情况:
- 肺部超声波 (LUS) 是一种非侵入性的床边工具,用于通过血管外肺水评估肺堵塞.
- 这种技术越来越多地被使用,因为它的可用性和准确性.
研究的目的:
- 为了比较LUS在体积状态评估中的有效性与临床评估,心声回声,生物阻抗和生物标志物的有效性.
- 评估LUS对所有原因死亡率和心血管事件的影响作为次要结果.
主要方法:
- 一个MEDLINE搜索确定了28项研究 (25项观察性,3项随机) 涉及LUS在维护透析的患者.
- 使用随机效应模型计算聚合相关系数,以评估LUS B线与各种临床/心声学参数之间的关系.
主要成果:
- 在临床参数中,纽约心脏协会功能分类 (r=0.57) 和肺部听觉 (r=0.36) 显示了与LUS B线最强的相关性.
- 左心室喷射率 (r=0.35) 和下静脉内腔指数 (r=0.31) 与LUS B线在心声学参数中最强相关.
- 随机试验表明,在LUS指导下,降血压和血压控制更好,但死亡率或主要心血管不良事件没有显著差异.
结论:
- 肺部超声波是鉴定透析患者亚临床体积过载的宝贵工具.
- 尽管改善了脱血和血压控制,但目前的证据不支持硬性临床结果 (死亡率,心血管事件) 的差异.
- 由于现有研究的数量有限和异质性,需要进一步进行高质量的试验.
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