有氧运动对结肠癌幸存者的炎症的剂量反应效应
Justin C Brown1,2,3,4, Stephanie L E Compton1, Jeffrey A Meyerhardt5
1Pennington Biomedical Research Center, Baton Rouge, LA, United States.
身体活动可以通过减少炎症来改善结肠癌的存活率,特别是在III期患者中. 低剂量运动在III期疾病中显著降低了炎症标志物,表明潜在的调解作用.
科学领域:
- 在瘤学瘤学.
- 运动科学 运动科学
- 免疫学 免疫学 免疫学
背景情况:
- 手术后的体力活动与结肠癌患者更好的无疾病生存率有关.
- 炎症是身体活动与生存结果之间的这种关联的潜在媒介.
研究的目的:
- 在结肠癌幸存者中研究有氧运动和炎症标志物之间的剂量反应关系.
- 探索癌症阶段是否会改变运动对炎症的影响.
主要方法:
- 一项随机试验的探索性分析,涉及39名结肠癌幸存者.
- 参与者被随机分配到24周的常规护理,低剂量 (150分钟/周) 或高剂量 (300分钟/周) 的有氧运动.
- 评估了炎症标志物 (hs-CRP,IL6,sTNFαR2) 和癌症阶段.
主要成果:
- 总的来说,运动并没有显示炎症标志物的剂量反应减少.
- 癌症阶段显著改变了运动对hs-CRP和IL6的影响.
- 在III期患者中,低剂量运动降低了hs-CRP和IL6,但高剂量运动没有.
结论:
- 初步发现支持这样的假设,即炎症可能会调解身体活动与改善结肠癌无病生存率之间的联系.
- 运动干预措施可能需要根据癌症阶段进行量身定制,以获得最佳的抗炎作用.
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