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植物细胞在生物反应器中的出现

Fuensanta Verdú-Navarro^1,2, Juan A Moreno-Cid¹, Julia Weiss²

¹Bioprocessing R&D Department, Bionet, Parque Tecnológico Fuente Álamo, Fuente Álamo, Spain.

Frontiers in plant science

|December 27, 2023

概括

生物反应器中的植物细胞培养为生产有价值的生物分子提供了一种新的方法. 本综述探讨了使用模型植物物种生产高质量的代谢物生成的生物反应器类型和协议.

科学领域:

植物生物技术植物生物技术
生物反应器技术技术
代谢物生产代谢物生产

背景情况:

传统农业专注于作物改进,但重组DNA技术使植物能够产生异源分子.
植物化学多样性是药品的关键来源,推动了植物生物技术的高质量代谢物合成.
尽管已建立植物组织培养,但与微生物或动物系统相比,植物细胞培养的生物技术影响有限.

研究的目的:

审查用于植物细胞生产的生物反应器类型.
讨论这些生物反应器用于生产优质生物分子的应用.
提供已建立的植物细胞培养模型和用于代谢物生产的物种的概述.

主要方法:

对生物反应器中植物细胞培养的当前文献的综述.
对不同生物反应器设计及其适用于植物细胞悬浮培养物的分析.
检查使用模型植物物种的特定代谢物的生产方案.

主要成果:

确定了各种适合植物细胞培养的生物反应器类型.
突出了植物细胞生物反应器在生产有价值的生物分子方面的潜力.
介绍了模型物种的概述,如 *Nicotiana tabacum *, *Oryza sativa *和 *Daucus carota *用于细胞培养.

结论:

生物反应器中的植物细胞培养是可持续生产高价值化合物的有希望的途径.
优化的生物反应器策略和协议对于最大限度地提高生物分子产量和质量至关重要.
对植物细胞生物反应器系统的进一步研究可以增强它们对制药,化品,农业和食品工业的贡献.

关键词:

在 SIP 生物反应器中,植物细胞培养植物细胞培养.它们是重组蛋白质.二次代谢产物二次代谢产物单次使用的生物反应器

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