巨细胞动脉炎:西挪威的发病率和表型分布 2013-2020年
H K Skaug1,2,3, B T Fevang2,3, J Assmus4
1Haugesund Hospital for Rheumatic Diseases, Haugesund, Norway.
Frontiers in medicine
|December 27, 2023
概括
巨细胞动脉炎 (GCA) 的表型各不相同,整体而言,骨GCA是最常见的. 非骨GCA在年轻患者中更频繁,经历了更长的诊断延迟.
科学领域:
- 类风湿病学 类风湿病学
- 血管炎研究 血管炎研究
- 流行病学 流行病学
背景情况:
- 巨细胞动脉炎 (GCA) 呈现出不同的表型,受遗传学和环境的影响.
- 关于GCA表型的分布和特征的数据有限.
研究的目的:
- 描述GCA在定义的挪威人口中的表型分布.
- 调查跨GCA表型的发病率和临床特征的差异.
主要方法:
- 在Bergen健康区 (2013-2020) 所有GCA患者的回顾性队列研究.
- 基于动脉活检 (TAB),超声波,FDG-PET/CT,MRI或CT血管造影的表型分类.
- 纳入标准:符合分类标准的临床可能的GCA.
主要成果:
- 整体GCA发病率:每10万年龄在50岁以上的人口中有20.7人.
- 骨GCA是主要的表型,但非骨GCA在60岁以下的患者中超过50%.
- 诊断延迟的时间是非骨/混合表型与骨GCA.的两倍.
结论:
- GCA的发病率与之前的区域报告一致.
- 虽然骨GCA占主导地位,但非骨GCA在年轻人 (<60岁) 中普遍存在.
- 非骨GCA的较长诊断延迟凸显了在怀疑GCA时需要更广泛的血管成像.
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