使用孕激素对甲状腺激素和新生儿类固醇水平的额外影响
Ana Carolina Rusca Correa Porto1, Mariana Abreu Redoan2, Cristina Oliveira Massoco3
1Universidade de Sorocaba, Faculdade de Medicina Veterinária, Sorocaba, SP, Brasil.
Animal reproduction
|December 27, 2023
概括
在怀孕晚期接受长期孕激素补充剂的母马增加了小的皮质激素水平,而阿尔特雷诺杰斯特降低了它们,没有观察到临床效应或母亲和小之间的孕激素相关性.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 生殖内分泌学 生殖内分泌学
- 马类科学 马类科学
背景情况:
- 外源性荷尔蒙补充剂,特别是孕激素,在马匹中用于防止怀孕流产.
- 这种补充对新生儿激素水平的影响以及与母体激素的潜在相关性需要彻底调查.
研究的目的:
- 为了评估甲状腺荷尔蒙和类固醇水平,用于补充合成孕激素的马产生的小马.
- 为了确定母亲和新生儿的孕激素水平之间是否存在相关性.
- 评估不同孕激素补充方案对新生儿激素特征的影响.
主要方法:
- 27只母马及其小马被分为五组:对照组和四个治疗组,每组服用不同时间和持续时间的孕激素或其他激素补充剂.
- 从母马 (孕激素) 和新生儿 (总T3,自由T4,TSH,孕激素,皮质素) 进行分娩后立即采集血液样本.
主要成果:
- 新生儿总T3,自由T4,TSH或孕激素水平在不同组之间没有发现显著差异.
- 母亲的孕激素水平在马群之间没有差异.
- 来自长期接受孕激素的母马的新生儿 (组4) 的皮质素水平较高,而来自接受阿尔特雷诺杰斯特的母马的新生儿 (组5) 的皮质素水平较低.
- 在孕产妇和新生儿的孕激素水平之间没有发现相关性.
结论:
- 晚期孕激素补充在马匹可以改变新生儿皮质素水平,而不会影响其他测量的激素或引起临床症状.
- 在怀孕后期服用阿尔特格斯特补充剂也会影响新生儿的皮质素水平,但与孕激素相反.
- 孕产妇的孕激素补充似乎与小的新生儿孕激素水平没有相关性.
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