肠道微生物群的组成与COVID-19中的疾病严重程度和宿主免疫反应有关
Ruyue Fan1,2, Shuai Liu3,4, Na Sun1,2
1Shandong Center for Disease Control and Prevention, Jinan, Shandong, China.
Frontiers in cellular and infection microbiology
|December 27, 2023
概括
在COVID-19患者中,肠道微生物组发生了变化,病原体增加,有益细菌减少. 这些变化与免疫状况和疾病严重程度相关,这表明它们在宿主反应中起作用.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 人的肠道微生物群影响宿主对呼吸道病毒感染的免疫反应.
- 关于肠道微生物组在COVID-19严重性和宿主免疫力中的作用的证据有限.
研究的目的:
- 为了研究COVID-19患者的肠道微生物组合.
- 了解肠道微生物群,免疫状态和COVID-19中的疾病严重程度之间的关系.
主要方法:
- 来自40名COVID-19患者和33名对照者的便样本的16S rRNA测序.
- 对肠道微生物组合和血液学参数的分析.
主要成果:
- COVID-19患者表现出改变的肠道微生物群,机会性病原体增加 (例如,菌,乳杆菌) 和共生细菌减少 (例如,Faecalibacterium,Roseburia).
- 严重的COVID-19病例显示出较高的菌和乳酸菌,以及较低的酸盐产生细菌.
- 便细菌的丰富度与淋巴细胞数量呈正相关,与中性粒细胞百分比呈负相关,可能区分严重病例.
结论:
- 肠道微生物组的改变与COVID-19有关.
- 肠道微生物组可能在调节宿主免疫反应和影响疾病严重程度方面发挥作用.
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