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针对SARS-CoV-2及其变种的抗病毒药物的临床开发

Qiaoshuai Lan^1,2, Yan Yan¹, Guangxu Zhang¹

¹Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China.

Current research in microbial sciences

|December 27, 2023

概括

由于SARS-CoV-2的传播,开发新的抗病毒药物至关重要. 本综述涵盖了COVID-19和其他人类冠状病毒治疗的临床进展.

科学领域:

病毒学病毒学
传染性疾病传染性疾病
药理学药理学是指药理学的学科.

背景情况:

由于SARS-CoV-2的全球传播,需要新的治疗方法.
目前的COVID-19治疗方法面临诸如有效性有限,对变种敏感性降低,口服生物利用性差等挑战.
迫切需要针对SARS-CoV-2及其变种和其他人类冠状病毒 (HCoV) 有效的强效,广泛的抗病毒药物.

研究的目的:

审查最近针对SARS-CoV-2感染的抗病毒疗法的临床发展.
突出针对SARS-CoV-2及其变体的治疗方法的进展.
为开发下一代抗病毒药物提供信息,具有改进的特性.

主要方法:

临床试验和针对COVID-19的抗病毒药物研究的文献综述.
对药物的疗效,药理动力学/药理动力学特性和活性谱的分析.
对针对SARS-CoV-2和HCoVs的抗病毒开发的当前数据的综合.

主要成果:

很少有抗病毒药物对抗COVID-19具有令人满意的临床疗效.
引起关注的SARS-CoV-2变种 (VOCs) 的出现导致药物敏感性降低.
局限的口服生物可用性限制了一些抗病毒药物的临床效用.

结论:

持续的研究对于开发有效和广泛适用的抗病毒药物至关重要.
未来的抗病毒药物必须具有增强的功效,更广泛的频谱活性和有利的药理动力学特征.
解决耐药性和生物可用性问题是对抗当前和未来的冠状病毒威胁的关键.

关键词:

抗病毒药物抗病毒药物在 COVID-19 疫情中,主机因素主机因素这就是SARS-CoV-2病毒.变种变种变种变种病毒因素是病毒因素.

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