新催眠药对认知的影响:系统性审查和网络元分析
Mengzhen Zhou1, Rujia Liu1,2, Jiyou Tang1
1Department of Neurology, the First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, PR China.
双素受体抗剂 (DORA) 建议用于治疗失眠,因为它们在改善睡眠的有效性而没有认知障碍. 其他睡眠药物,如佐洛皮,可能更适合短期使用,而埃斯托皮克隆和索皮克隆则需要进一步验证认知效果.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
背景情况:
- 失眠是一种普遍的疾病,有关各种睡眠药物的认知影响的争论仍在进行中.
- 不同剂量的催眠药可以产生不同的结果,需要清楚地了解它们对认知的影响.
研究的目的:
- 评估不同剂量的抗失眠药物诱导的认知障碍,包括双素受体对抗剂 (DORA),佐皮克隆,埃索皮克隆和佐尔皮德姆.
- 为选择适合失眠治疗的药物治疗方案提供临床指导的基础.
主要方法:
- 随机对照试验 (RCT) 的系统审查和元分析使用PubMed,Embase,Scopus,Cochrane Library和Google Scholar的数据进行,截至2022年9月20日.
- 主要结局包括认知功能测试 (例如数字符号替换测试) 和白天警觉. 二次结果集中在睡眠质量和不良事件上.
主要成果:
- 对29项涉及8702名参与者的研究分析显示,高剂量埃斯托皮克隆与安慰剂和其他几种药物治疗方案相比,显著增加了白天的警觉性.
- 双素受体对抗剂 (DORA) 与安慰剂和其他测试药物相比显著增加了总睡眠时间 (TST),没有报告认知障碍.
结论:
- 双素受体抗剂 (DORA) 被推作为不眠症的首选干预措施,提供有效的睡眠诱导和维持,没有不良的认知影响.
- 虽然佐尔皮德姆有助于维持睡眠,但建议短时间使用. eszopiclone 和 zopiclone 的认知影响需要进一步研究.
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