1-基对诺普拉桑引起的微生物组变化的影响:一项随机,双盲,安慰剂控制的试点研究
Satoshi Furune1,2, Takahiro Suzuki2, Takashi Honda2
1Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Japan.
Journal of gastroenterology and hepatology
|December 27, 2023
概括
作为一种益生菌的1-kestose,可以预防由竞争性酸阻断剂引起的肠道失调. 这表明1-kestose可能是对失生症的有用治疗方法,提供对微生物组变化的预防措施.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 药理学 药理学是指药理学的学科.
背景情况:
- 竞争性酸阻断剂 (P-CABs) 有效抑制胃酸,但可以诱导肠道失调.
- 针对P-CAB诱导的抗生素失调的预防策略尚未得到充分确立.
- 一种益生菌的1-kestose正在研究其减轻这些微生物组变化的潜力.
研究的目的:
- 评估1-基在预防或减轻由竞争性酸阻断剂诱导的失生症方面的疗效.
- 评估在P-CAB治疗期间1-kestose对便微生物组合物的影响.
主要方法:
- 一项随机对照试验,涉及为胃口瘤进行内镜切除的患者.
- 参与者接受了1-kestose (10克/天) 或安慰剂 (马尔托斯) 与vonoprazan (20毫克/天) 一起服用8周.
- 使用16S rRNA基因测序 (V3-V4区域) 的便微生物组分析在治疗前和治疗后进行.
主要成果:
- 在安慰剂组中,观察到阿尔法多样性 (辛普森指数) 的显著下降和链球菌相对丰度的增加.
- 1基糖组在α多样性上没有显著的变化,并且在Streptococcus中没有显著的增加.
- 没有报告任何不良事件,的愈合在两组中都足够.
结论:
- 竞争性酸阻塞剂在安慰剂组中诱导了显著的肠道失调.
- 服用1-kestose有效地预防了与P-CAB治疗相关的失生症.
- 1-基作为治疗P-CAB诱导的失生症的治疗药物具有前景.
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