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[李丹赫吉颗粒的急性毒性测试]

Mengjie Su1, Huan Qin2, Wei Yi3

  • 1Clinical College of Traditional Chinese Medicine, Hubei University of Chinese Medicine, Wuhan 430065, Hubei, China.

Zhonghua wei zhong bing ji jiu yi xue
|December 27, 2023
PubMed
概括

在小鼠中,Li-Dan-He-Ji颗粒显示出较低的口服毒性. 急性毒性研究表明,颗粒是安全的使用,没有观察到显著的不良影响.

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...