怀孕期间作为自闭症谱系障碍的病因因素的孕产妇甲状腺功能障碍:研究的挑战和机会
Zoe B Kaplan1, Elizabeth N Pearce2, Sun Y Lee2
1Department of Public Health Sciences, School of Medicine, University of California, Davis, Davis, California, USA.
Thyroid : official journal of the American Thyroid Association
|December 27, 2023
概括
怀孕期间母亲的甲状腺功能障碍,特别是甲状腺功能低下,与儿童患自闭症谱系障碍 (ASD) 的可能性增加有关. 需要进一步的研究来证实这种联系,并探索有助于因素.
科学领域:
- 神经发育障碍 神经发育障碍
- 内分泌学 在内分泌学.
- 环境健康 环境健康
背景情况:
- 自闭症谱系障碍 (ASD) 的病因是复杂的,涉及遗传和环境因素.
- 产前环境暴露越来越被认为是导致自闭症发展的潜在因素.
- 怀孕期间母亲的甲状腺功能是胎儿神经发育的关键因素.
研究的目的:
- 审查和批判性地检查证据,将孕期母亲甲状腺功能障碍与后代的自闭症相关联.
- 综合各种形式的母体甲状腺功能障碍的研究结果,包括甲状腺功能低下,甲状腺功能过高和自身免疫性甲状腺疾病.
- 确定现有研究中的局限性和偏见,并建议未来的方向.
主要方法:
- 基于人口的研究和医疗记录分析的叙述性审查.
- 包括评估甲状腺功能低下症,甲状腺功能过高症,甲状腺功能低下症,甲状腺激素水平和自身免疫性甲状腺疾病的研究.
- 分析潜在的偏见,如错误分类,生存和出版偏见.
主要成果:
- 大多数研究表明,母体甲状腺功能低下症与儿童患ASD诊断的可能性较高之间存在积极的关联.
- 与其他母亲甲状腺功能障碍的关联不太一致.
- 潜在的偏见,包括亚临床功能障碍的错误分类和ASD早期评估,可能会影响研究结果.
结论:
- 有证据表明,怀孕期间母亲甲状腺功能障碍与ASD结果之间存在联系,甲状腺功能低下是显著的因素.
- 未来的研究应该利用实验室措施来准确评估甲状腺功能障碍和可靠的ASD检测年龄.
- 需要进一步调查母亲的Levothyroxine治疗,缺乏症和破坏甲状腺的化合物.
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