在患有过度活跃膀的患者中,真实世界上的abotulinumtoxinA治疗模式
Bilal Chughtai1, Christine N Ricker2, Ryan J Boldt2
1Department of Urology, Weill Cornell Medicine, New York, New York, USA.
Neurourology and urodynamics
|December 27, 2023
概括
过度活跃的膀 (OAB) 治疗上胺毒素A 经常被提前停止. 大多数停止治疗的患者不会寻求替代疗法,这表明有未满足的需求.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 过度活跃的膀 (OAB) 显著影响生活质量.
- 对OAB的第三线治疗模式,特别是对abotulinumtoxinA的治疗模式,没有得到很好的描述.
- 了解治疗利用和停止对于解决OAB管理中未满足的需求至关重要.
研究的目的:
- 分析用于OAB的onabotulinumtoxinA的利用模式.
- 调查停药率和随后的治疗选择.
- 确定OAB治疗选择中未得到满足的需求.
主要方法:
- 对非识别的行政索赔数据 (2009-2021) 的回顾性分析.
- 在2015-2017年期间,包括OAB患者启动纳博胺毒素A的患者.
- 在治疗前18个月和治疗后至少36个月的治疗模式的评估.
主要成果:
- 21.4%的患者继续接受abotulinumtoxinA,其中57%接受≥5次治疗.
- 78.6%的人停止了治疗,其中84%的人接受了≤2次治疗.
- 药物使用在两组中同样下降;神经神经调节在停药者 (7%) 比继续使用者 (3%) 更常见.
结论:
- 在OAB治疗中,早点停止使用onabotulinumtoxinA是很普遍的.
- 大多数停止使用abotulinumtoxinA的患者不会接受替代治疗.
- 有机会教育患者其他OAB治疗选择.
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