PRAME表达:癌症免疫治疗的目标和Uveal黑色素瘤的预后因素
Maria Chiara Gelmi1, Gulçin Gezgin1, Pieter A van der Velden1
1Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.
Investigative ophthalmology & visual science
|December 27, 2023
概括
在黑色素瘤中优先表达的抗原 (PRAME) 与阴道黑色素瘤 (UM) 的较差结果有关. 针对PRAME的免疫疗法显示为这种罕见癌症的潜在治疗方法.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
背景情况:
- 卵巢黑色素瘤 (UM) 是一种罕见的,高死亡率的眼睛癌症,治疗选择有限.
- 在黑色素瘤中优先表达的抗原 (PRAME) 是一种在UM和其他恶性瘤中发现的癌症丸抗原.
- 由于其在瘤细胞中的表达,PRAME是癌症免疫治疗的潜在目标.
研究的目的:
- 为了研究PRAME表达在皮膜黑色素瘤中的作用.
- 评估PRAME作为UM免疫治疗的潜在目标.
- 为了将PRAME表达与瘤特征和预后相关联.
主要方法:
- 关于各种癌症中PRAME表达的文献综述,包括UM.
- 在两个队列 (LUMC和TCGA) 中,高PRAME和低PRAME的UM患者之间的瘤特征的比较分析.
- 在LUMC队列中的差异基因表达分析.
主要成果:
- 在26-45%的UM病例中表达了PRAME,并与更糟糕的预后有关.
- 高PRAME表达与较大的瘤直径,高级TNM阶段,染色体8q增长和炎症表型相关.
- 通过PRAME特异性T细胞受体 (TCR) 转导的T细胞证明了对UM细胞的有效性.
结论:
- 证实PRAME表达是UM中预后不佳的标志物,与8q染色体变化有关.
- 特定于PRAME的免疫疗法,特别是辅助疗法,是UM和其他恶性瘤的有前途的治疗策略.
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