消除艾滋病毒组织储存:当前的战略和挑战
1National Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Infectious diseases (London, England)
|December 27, 2023
概括
消除人类免疫缺陷病毒 (HIV) 储备是治愈获得性免疫缺陷综合征 (AIDS) 的关键. 目前的研究探讨了基因治疗和免疫治疗等各种策略,但需要更多的研究来证实有效性.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
背景情况:
- 获得性免疫缺陷综合征 (艾滋病) 仍然是一个全球卫生挑战,主要是由于人类免疫缺陷病毒 (HIV) 持续存在的储备.
- 抗逆转录病毒疗法 (ART) 可以控制病毒载量,但不能消除这些潜伏的储存库,这些储存库在停止治疗后会导致反弹病毒症.
研究的目的:
- 审查目前旨在消除艾滋病毒组织储存的策略和治疗方法.
- 通过准艾滋病毒储存库,评估研究取得的进展和初步性质,以实现对艾滋病的功能治疗.
主要方法:
- 系统性文献审查遵循系统性审查和元分析 (PRISMA) 准则的首选报告项目.
- 在Pubmed,Embase和Scopus数据库中搜索了过去十年 (至2023年6月) 出版的文学作品.
主要成果:
- 审查了各种策略,包括早期/强化疗法,基因疗法 (例如,CRISPR/Cas9,TALENs),"冲击和杀死","阻止和锁定",免疫疗法 (例如,治疗疫苗,CAR-T,bNAbs) 和造血干细胞移植 (HSCT).
结论:
- 艾滋病毒储存库是完全治愈艾滋病的主要障碍.
- 虽然正在进行重大研究,但目前的策略是初步的,需要进一步调查它们的可靠性,有效性和功能治疗的必要性.
相关概念视频
01:10Retrovirus Life Cycles
46.0K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
46.0K
01:26Sexually Transmitted Infections
316
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
316