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在患有多发性硬化症的患者中进行腹腔外科手术和二甲基烟酸诱导的淋巴衰竭

Valentina Andreozzi¹, Rocco Capuano², Sara Scannapieco¹

¹Neurology Unit, University Hospital "San Giovanni di Dio E Ruggi d'Aragona", Largo Città di Ippocrate, 84100, Salerno, Italy.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

|December 27, 2023

概括

丁甲基烟酸 (DMF) 可以导致多发性硬化症患者的淋巴缺血. 在DMF的腹腔外科手术患者经历了持续的淋巴缺血,突出显示了监测绝对淋巴细胞计数的必要性.

科学领域:

神经学神经学
药理学药理学是指药理学的学科.
胃肠病学胃肠病学

背景情况:

丁甲基烟酸 (DMF) 是一种用于治疗多发性硬化症 (MS) 的疾病修饰疗法 (DMT).
淋巴缺血是DMF治疗的一个已知的副作用.
较高的体重指数 (BMI) 可能有助于预防DMF诱导的淋巴缺血症,但缺乏在腹部外科手术后减肥的患者的数据.

研究的目的:

为了调查患有多发性硬化症 (pwMS) 的患者发生淋巴缺血的情况,这些患者接受了减肥手术,并接受了DMF治疗.

主要方法:

案例系列描述了两名pwMS患有减肥手术史,他们开始了DMF治疗.
在DMF治疗期间监测绝对淋巴细胞计数.

主要成果:

两位pwMS在使用DMF时都经历了持续的淋巴缺血.
在停止使用DMF后,淋巴缺血症在两名患者中都消失了.

结论:

腹腔外科手术和随后的体重减轻可能会改变DMF的药理动力学和生物可用性,可能会增加淋巴衰竭的风险.
建议密切监测绝对淋巴细胞计数,以DMF治疗的PwMS患者,他们有空腹手术和减肥病史.

关键词:

腹部外科手术是什么意思双甲基烟酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸淋巴细胞减少症 (Lymphopenia) 是一种风险因素风险因素

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