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焦虑障碍中的灰质结构变化:基于voxel的元分析

Han Liu^1,2, Zeqi Hao^1,2, Shasha Qiu^1,2

¹School of Psychology, Zhejiang Normal University, Jinhua, China.

Brain imaging and behavior

|December 27, 2023

概括

这一元分析确定了焦虑症 (AD) 中常见的大脑灰质体积异常. 与健康对照人群相比,患有AD的患者在包括胰岛,乳头和尾骨在内的区域显示灰质量变化.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
医疗成像医学成像

背景情况:

焦虑障碍 (ADs) 是一种普遍存在的精神疾病,其神经病理不清楚.
之前使用基于声素的形态测量 (VBM) 的研究表明,在ADS中灰质体积 (GMV) 异常方面存在不一致的发现.

研究的目的:

通过对个别研究进行元分析来确定AD中常见的GMV异常.
巩固现有研究并澄清ADS的神经病理基础.

主要方法:

在PubMed,Embase和Web of Science的系统文献搜索.
使用异型效应大小签名差异映射 (AES-SDM) 的元分析.
包括24项研究,包括906名AD患者和1003名健康对照 (HC).

主要成果:

与HCs相比,AD患者的左上顶顶状,右角,左前中心和右舌状的GMV增加.
与HC相比,AD患者的双边胰岛,双边 thalamus,左尾骨和右骨中的GMV减少.

结论:

确定了与AD病理学相关的异常GMV的特定大脑区域.
这些发现有助于更好地了解焦虑症背后的神经病理机制.

关键词:

焦虑症焦虑症焦虑症灰色物质的体积,灰色物质的体积.进行元分析分析.基于voxel的形态测量方法

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