拔牙之前和之后是否需要取消抗吸收剂的使用? 一个系统的审查
Daisuke Takeda1, Hiroshi Kurita2, Yoshihisa Kashima3
1Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Clinical oral investigations
|December 27, 2023
概括
这一系统性审查没有发现任何证据表明,停止抗吸收药物可以预防牙拔牙后与药物相关的骨缩 (MRONJ). 需要更多的研究来确定这些药物的患者是否需要停药.
科学领域:
- 在口腔外科手术.
- 药理学 药理学是指药理学的学科.
- 在瘤学瘤学.
背景情况:
- 与药物相关的骨 (MRONJ) 是使用抗吸收剂的患者日益关注的问题.
- 管理策略,包括药物戒断,对于患者安全至关重要.
研究的目的:
- 系统地审查是否需要在拔牙时使用抗吸收剂.
- 评估抗吸收剂撤销对MRONJ发病率和潜在危害的影响.
主要方法:
- 系统的文献审查,包括SR,RCT,观察性研究和病例报告.
- 在MEDLINE数据库中进行的搜索.
- 由于研究异质性和小样本大小,元分析是不可行的.
主要成果:
- 没有研究表明短期抗吸收药物撤销在牙拔除后减少MRONJ发病率方面有好处.
- 没有研究评估了戒断的潜在危害,例如骨折风险增加.
结论:
- 目前的证据不足以确定是否需要取消抗吸收药物取消牙提取.
- 需要使用更大的样本大小的高质量的RCT来建立基于证据的指导方针.
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