将种族系数添加到4K得分中,改善了黑人男性的校准
Helen Y Hougen1, Daniel D Sjoberg2, Jamie Thomas3
1Department of Urology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.
一个新的种族系数提高了黑人男性的4Kscore测试准确度,提高了前列腺癌风险评估. 这种调整更好地校准了这个人口群体的预测和临床效用.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 医学诊断 医学诊断 医学诊断
背景情况:
- 与非黑人男性相比,黑人男性患前列腺癌 (PCa) 的高风险发病率更高.
- 4Kscore是PCa风险分层的验证工具,但目前没有纳入种族因素.
研究的目的:
- 描述和验证4Kscore的预规定的比赛系数.
- 为了提高黑人男性4Kscore的准确性.
主要方法:
- 使用85名黑人男性的数据预先指定了0.6的种族系数.
- 4Kscore的歧视,校准和临床实用性在205名黑人男性的队列中被评估,并没有系数.
- 对组合队列进行了敏感性分析.
主要成果:
- 高度PCa的平均概率随着比赛系数的增加而从25%增加到37%.
- 将系数纳入改善了4Kscore校准和黑人男性的临床效用.
- 在联合队列中,模型歧视保持稳定 (AUC为0.825对0.828).
结论:
- 黑人种族的预规定的系数提高了4Kscore的校准和临床效用.
- 建议增加这个种族系数,以改善黑人男性前列腺癌风险评估.
更多相关视频
06:55Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
Published on: January 8, 2020
08:27Applying an eMASS Customization Program as a Research Tool to Evaluate Consumer Benefits
Published on: September 27, 2019
相关概念视频
Calibration Curves: Correlation Coefficient
Factors Affecting Activity Coefficient
The activity coefficient value for an ion is close to one when the solution has almost zero ionic strength, i.e., when the solution shows close to ideal behavior. As the ionic strength of the solution increases from 0 to 0.1 mol/L, a...
Calibration Curves: Linear Least Squares
For data that follow a straight line, the standard method for fitting is the linear...
Coefficient of Correlation
If you suspect a linear relationship between x and y, then r can measure how strong the linear relationship is.
What the VALUE of r tells us:
The value of r is always between –1 and +1: –1 ≤ r ≤ 1.
The size of the correlation r indicates the...
Kendall's Coefficient of Concordance
Calculating and Interpreting the Linear Correlation Coefficient
