手术抗生素预防的理想持续时间是多少?
1Department of Surgery, Division of General Surgery, University of Washington, Seattle, Washington, USA.
Surgical infections
|December 27, 2023
概括
自20世纪70年代以来,手术抗生素预防是一种常见的做法,越来越多的证据支持更短的持续时间. 目前的指导方针建议在切口关闭后避免使用抗生素,以优化患者护理.
科学领域:
- 传染性疾病 传染性疾病
- 在外科手术实践中.
- 药理学 药理学是指药理学的学科.
背景情况:
- 自20世纪70年代以来,手术抗生素预防 (SAP) 已成为治疗的标准.
- 最初的SAP协议涉及12小时的多次剂量,第一次剂量是在手术前.
- 实践已经发展,越来越多的证据影响了持续时间建议.
研究的目的:
- 审查关于手术抗生素预防的持续时间的历史演变和当前证据.
- 突出转向在手术环境中使用抗生素的时间较短的转变.
- 为了强调最近关于停止预防治疗的指导方针建议,切口后关闭.
主要方法:
- 关于手术抗生素预防的历史文章和当代证据的文献综述.
- 随着时间的推移,分析预防持续时间和剂量策略的趋势.
- 检查有影响力的指导方针及其建议.
主要成果:
- 手术抗生素预防在20世纪70年代变得广泛.
- 早期的做法倾向于更长的持续时间 (例如,三个剂量超过12小时).
- 目前的证据越来越多地支持更短的持续时间,指南建议不要在关闭后进行管理.
结论:
- 几十年来,手术抗生素预防的持续时间显著缩短.
- 有证据支持将抗生素暴露最小化,以减少风险和优化结果.
- 目前的最佳实践,在指导方针的支持下,涉及合理使用抗生素,通常在切口关闭后停止使用.
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