唾液腺癌的全身疗法:已发表的临床试验概述
L-C Silva1, M-E Pérez-de-Oliveira, C-M Pedroso
1Department of Oral Diagnosis Piracicaba Dental School, University of Campinas Av Limeira, 901, Postal code:13414-016, Piracicaba, São Paulo, Brasil pavargas@unicamp.br.
Medicina oral, patologia oral y cirugia bucal
|December 27, 2023
概括
唾液腺癌的全身疗法 (ST) 缺乏共识. 临床试验显示反应率较低,突出显示需要分子标识和有效的ST开发.
科学领域:
- 在瘤学瘤学.
- 医学研究 医学研究
- 临床试验 临床试验
背景情况:
- 唾液腺癌 (sgcs) 缺乏有效的全身疗法 (ST) 的共识.
- 目前对SGCS的治疗策略需要进一步的研究和验证.
- 了解不同系统疗法的疗效对于改善患者的治疗结果至关重要.
研究的目的:
- 总结临床试验评估系统疗法 (ST) 唾液腺癌 (sgcs).
- 评估各种药物在治疗不同组织学亚型SGCS治疗中的有效性.
- 为了确定潜在的治疗目标和有效的ST疗法对 sgcs.
主要方法:
- 在主要数据库中进行了全面的电子搜索,包括MEDLINE/PubMed,EMBASE,Scopus,Web of Science和Cochrane图书馆.
- 还包括灰色文献,以确保对可用的临床试验进行彻底审查.
- 在确定的研究中,评估了17种不同的药物.
主要成果:
- 腺性囊性癌是最常见的组织学亚型 (45.5%).
- 苏尼蒂尼布在腺囊性癌症中显示出稳定疾病的最高率.
- 在雄激素受体阳性瘤中,烯酸显示出最高的完全 (11.1%) 和部分 (30.5%) 应答率.
结论:
- 尽管取得了进展,但对于sgcs.sgcs.没有建立基于证据的ST疗法.
- 所有确定的临床试验报告了完全和部分反应的低率.
- 进一步的翻译研究对于确定分子标和开发有效的ST用于sgcs至关重要.
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