儿科队列中的SARS-CoV-2再感染 - - 一个单一中心的经验
Asli Arslan1, Zumrut Sahbudak Bal1, Ece Erci1
1Division of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Ege University, Izmir 35040, Turkey.
Journal of tropical pediatrics
|December 27, 2023
概括
儿科SARS-CoV-2再感染很常见,即使在健康的儿童中也是如此,但不会导致更严重的结果. 欧米克朗变种增加了症状再感染的风险.
科学领域:
- 传染性疾病 传染性疾病
- 儿科 儿科 儿科
- 病毒学 病毒学
背景情况:
- 了解重症急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 在儿童中再感染的临床结果至关重要.
- 主导的SARS-CoV-2变种已经进化,需要研究它们对儿科再感染模式和严重性的影响.
研究的目的:
- 为了确定患有SARS-CoV-2再感染的儿科患者的疾病严重程度和结果.
- 分析儿童SARS-CoV-2再感染中的感染发作和主导变异的时间表.
主要方法:
- 儿科患者 (0-18岁) 病历的回顾性评估,结果为SARS-CoV-2 PCR检测呈阳性.
- 纳入标准:在2020年3月至2022年9月期间在伊格大学儿童医院住院或门诊病人的身份.
主要成果:
- 分析了91名患有SARS-CoV-2再感染的儿科患者,26.4%患有潜在疾病.
- 感染之间的中位时间为184天,观察到从Delta变种转移到Omicron BA.1和BA.4/BA.5的变种.
- 再感染与更高的症状频率 (94.5% vs 84.6%) 相关,但住院率显著降低 (7.6% vs 15.3%).
结论:
- 儿童的SARS-CoV-2再感染,即使在健康的儿童中,也不会导致更严重的疾病结果.
- 奥米克朗变种的出现有助于在儿科患者群体中增加症状再感染的高风险.
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