在淡水藻Cyclotella meneghiniana中,物种诱导了代谢重编程
João P Santos1, Weiwei Li2, Arturo A Keller2
1University of Geneva, Faculty of Sciences, Earth and Environment Sciences, Department F.-A. Forel for Environmental and Aquatic Sciences, Environmental Biogeochemistry and Ecotoxicology, 66 Blvd Carl-Vogt, CH 1211 Geneva, Switzerland.
Journal of hazardous materials
|December 27, 2023
概括
单甲 (MeHg) 和无机 (Hg) 改变了藻的新陈代谢,MeHg导致了更显著的变化. 这项研究揭示了藻暴露在物种中的关键代谢转变.
科学领域:
- 环境科学 环境科学
- 生物化学 生物化学
- 生态毒理学 生态毒理学
背景情况:
- 是一种全球性污染物,已知对植物浮游生物有有害影响.
- 关于对藻类的特定代谢影响存在知识差距.
研究的目的:
- 研究藻Cyclotella meneghiniana中的代谢干扰.
- 比较无机 (Hg) 和单甲 (MeHg) 对藻代谢的影响.
主要方法:
- 有针对性的代谢组学.
- 生物积累测定试验
- 生理反应检测测定位测试
- 暴露于纳米分子Hg (II) 和MeHg2小时.
主要成果:
- Hg物种重新编程了氨基酸,核酸,脂肪酸,碳素酸和抗氧化剂的新陈代谢.
- 单甲基 (MeHg) 诱导的代谢重编程比Hg (II) 更明显.
- 在较高度下,Hg(II) 显示出明显的生理反应和更强大的代谢干扰.
结论:
- 短期暴露于会显著改变藻的新陈代谢.
- 代谢变化依赖于物种,MeHg的影响更大.
- 提供了关于藻中毒性的分子基础的见解.
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