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长非编码RNA LINC00491通过调节miR-508-3p/SATB1轴和激活Wnt信号通路来加速头支状细胞癌的进展

Dan Cui¹, Zexi Li¹, Chao Wei¹

¹Department of Stomatology, the First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China.

|December 27, 2023

概括

长跨基因非蛋白编码RNA 491 (LINC00491) 通过调节miR-508-3p/SATB1轴和激活Wnt信号通路,促进头支状细胞癌 (HNSCC) 的进展.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

头角状细胞癌 (HNSCC) 是一种常见的恶性瘤.
长非编码RNAs (lncRNAs) 在HNSCC发育中发挥作用.
LINC00491与癌症进展有关.

研究的目的:

研究LINC00491在HNSCC中的生物功能.
为了阐明LINC00491在HNSCC进展中的调节机制.

主要方法:

用RT-qPCR分析LINC00491的表达式.
细胞检测 (EdU,殖民地形成,伤口愈合,西斑) 对于增殖,亡,迁移和入侵.
RNA下拉和RIP测试以确定RNA相互作用.

主要成果:

在HNSCC细胞中,LINC00491的表达率很高.
LINC00491的枯竭抑制了HNSCC细胞的增殖,迁移和EMT.
LINC00491与 miR-508-3p 结合,而 miR-508-3p 的目标是 SATB1.
LINC00491通过SATB1.1激活了Wnt信号通道.

结论:

LINC00491促进了HNSCC的进展.
LINC00491通过miR-508-3p/SATB1轴调节HNSCC. 通过miR-508-3p/SATB1轴调节HNSCC.
在HNSCC中,LINC00491激活了Wnt信号通路.

关键词:

头部和部状细胞癌瘤现在我们来看一下LINC00491.在SATB1中,SATB1是SATB1.在 miR-508-3pp 中.

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