循环粘附分子在精神分裂症中的病理生理学作用:系统性审查和元分析
Angelo Zinellu1, Arduino A Mangoni2
1Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
Schizophrenia research
|December 27, 2023
概括
这项研究发现大多数细胞粘附分子和精神分裂症之间没有显著的关联,除了患者的P-选择素水平较高. 需要进一步的研究来了解精神分裂症,动脉样硬化和心血管疾病之间的联系.
科学领域:
- 神经科学是一个神经科学.
- 心血管科学 心血管科学
- 免疫学 免疫学 免疫学
背景情况:
- 精神分裂症越来越多地与动脉样硬化有关.
- 细胞粘附分子在早期动脉样硬化中起着至关重要的作用.
- 这项研究研究了这些分子在精神分裂症患者身上.
研究的目的:
- 系统地审查和元分析精神分裂症中细胞粘附分子.
- 评估精神分裂症,动脉样硬化和心血管疾病之间的关联.
主要方法:
- 对19项病例控制研究进行了系统审查和元分析.
- 在VCAM-1,ICAM-1,PECAM-1,NCAM,DSCAM,selectins,integrins和cadherins的数据库中进行了搜索.
- 使用JBI检查表和GRADE评估了偏见风险和证据确定性.
主要成果:
- 精神分裂症患者和对照人群之间大多数细胞粘附分子的非显著差异.
- 在精神分裂症患者中观察到升高的P-选择因水平 (SMD=2.05,p=0.003;非常低的确定性).
- 超回归揭示了ICAM-1/VCAM-1和药理治疗之间的关联,以及用于ICAM-1的矩阵.
结论:
- 目前的证据不支持免疫球蛋白类粘附分子,选择素,整合素或干素在精神分裂症 - 动脉样硬化症中发挥重要作用.
- 需要进一步的研究来探索这些关联以及抗精神病治疗的影响.
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