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EphB3蛋白是甲状腺癌的潜在辅助诊断生物标志物

Xinyue Gao¹, Rusong Zhang¹, Yan He¹

¹Department of Pathology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210002, China.

Annals of diagnostic pathology

|December 27, 2023

概括

乙型乙烯受体3 (EphB3) 在大多数乳头甲状腺癌 (PTC) 和骨髓甲状腺癌 (MTC) 中表达高. 精细针吸收细胞学 (FNAC) 中的EphB3表达可以帮助区分甲状腺癌和良性结节.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
病理学病理学病理学

背景情况:

甲状腺瘤需要准确的诊断生物标志物.
乙型乙烯受体3 (EphB3) 是各种癌症的潜在标记物.

研究的目的:

为了评估甲状腺瘤中的EphB3表达.
确定EphB3作为甲状腺瘤辅助诊断生物标志物的实用性.

主要方法:

通过使用EphB3抗体,对78个固定在甲,嵌入 (FFPE) 的组织样本和57个细针吸入细胞学 (FNAC) 样本进行了免疫组织化学检查.
皮肤状甲状腺癌 (PTC) 和其他甲状腺毛囊瘤之间的EphB3表达被比较.
桑格测序被用来检测BRAF V600E突变.

主要成果:

在81.8%的PTC和83.3%的MTC中,EphB3呈阳性.
在良性卵泡结节中,EphB3的表达显着较低 (例如,在超塑性/腺类结节中25%,在卵泡腺瘤中14.3%),在不确定的恶性瘤 (FT-UMP),NIFTP,卵泡癌,哈西莫托甲状腺炎和正常甲状腺组织的卵泡瘤中不存在.
在FNAC细胞块中,EphB3在87.1%的PTC和75%的MTC中呈阳性,但在不确定的重要性/不确定的重要性囊病变 (AUS/FLUS) 和正常的甲状腺细胞中呈阴性.

结论:

埃弗B3主要表达在恶性甲状腺瘤中,如PTC和MTC.
在良性甲状腺病变和某些前体病变中,EphB3的表达显著下降.
在FNAC中,EphB3可以作为一种有价值的辅助诊断工具,以区分甲状腺癌与良性卵泡病变,特别是AUS/FLUS.

关键词:

在 EphB3 中.在FNAC中,FNAC是FNAC.免疫组织化学免疫组织化学乳头甲状腺癌是一种乳头甲状腺癌.甲状腺癌是什么?甲状腺癌是什么?

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