牙周炎与轻度认知障碍之间的关联:系统性审查和元分析
Jieling Lin1, Janak L Pathak1, Yuqin Shen1
1Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, China.
Dementia and geriatric cognitive disorders
|December 27, 2023
概括
牙周炎增加了发展轻度认知障碍 (MCI) 的风险. 患有MCI的个体也表现出较差的牙周健康状况,包括更大的牙连接损失和斑块指数,突出显示了牙疾病和认知能力下降之间的重要联系.
科学领域:
- 医学研究 医学研究
- 公共卫生 公共卫生
- 神经科学是一个神经科学.
背景情况:
- 牙周炎是一种慢性炎症性疾病,影响牙.
- 轻度认知障碍 (MCI) 是正常衰老预期的认知衰退和痴呆症更严重的衰退之间的中间阶段.
- 牙周炎和MCI之间的关联正在调查中.
研究的目的:
- 系统地审查和分析有关牙周炎与患MCI风险之间的关系的现有文献.
- 为了确定患有MCI的个体与对照人群相比,牙周健康状况是否较差.
主要方法:
- 在PubMed,Scopus,Embase和Web of Science数据库中进行了全面的文献搜索,截至2023年4月.
- 七项涉及3973名参与者的研究被纳入了元分析.
- 计算了 95% 置信区间 (CI) 的聚合赔率比率 (OR) 和平均差异 (MD).
主要成果:
- 分析显示,牙周炎患者中MCI的发病率显著更高 (OR = 1.70).
- 严重的牙周炎显示MCI的风险更高 (OR = 2.09).
- 患有MCI的患者表现出增加的附着损失 (MD = 0.44) 和斑块指数 (MD = 0.72),但没有口袋探测深度.
结论:
- 牙周炎是发展MCI的一个重要风险因素.
- 在MCI患者中,牙周健康受到损害.
- 建议进一步进行高质量的研究,以巩固MCI和牙周炎之间的联系.
相关概念视频
01:26Alzheimer's Disease: Overview
491
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
491
01:30Dementia
115
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
115
01:15Teeth
431
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
431