Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Bioequivalence: Overview01:16

Bioequivalence: Overview

1.0K
Pharmaceutical equivalents, by definition, are drug products with the same active ingredient in the same quantities, encapsulated in identical dosage forms, and intended for the same administration routes. These pharmaceutical equivalents are deemed bioequivalent if the bioavailability of the active entity in the drug preparations is similar. Moreover, pharmaceutical equivalents demonstrating bioequivalence are also regarded as therapeutically equivalent. This means that when used as directed,...
1.0K
Target Cell Response to Hormones01:22

Target Cell Response to Hormones

3.1K
Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
3.1K
Types of Hormones01:21

Types of Hormones

3.2K
Hormones are classified into four main groups: steroids, eicosanoids, amino acid-based derivatives, and peptide hormones.
Steroids and eicosanoids fall under the category of lipid-soluble hormones. Steroids are derived from cholesterol and feature four interconnected carbon rings with variable side chains. Notable examples include estradiol from ovaries and testosterone from testes, exemplifying the critical roles of these lipid-soluble hormones in reproductive physiology. Eicosanoids, derived...
3.2K
Drug Biotransformation: Overview01:16

Drug Biotransformation: Overview

2.4K
Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
2.4K
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

402
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
402
Regulation of Hormone Secretion01:19

Regulation of Hormone Secretion

3.4K
Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral...
3.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Correction: Regulatory actions of LH and follicle-stimulating hormone on breast cancer cells and mammary tumors in rats.

Frontiers in endocrinology·2026
Same author

Development of a Realistic Physical Phantom for Laparoscopic and Robotic-Assisted Sacrocolpopexy Training and Associated.

IEEE journal of translational engineering in health and medicine·2026
Same author

A clinically and technologically practicable navigation system for robotic sacrocolpopexy.

International journal of computer assisted radiology and surgery·2026
Same author

Retraction notice to "The use of oral nomegestrol acetate/estradiol in rapid and random start preparation of endometrium before office hysteroscopic polypectomies: A multicenter, prospective, randomized controlled trial" [Eur. J. Obstet. Gynecol. Reprod. Biol. 299 (2024) 213-218].

European journal of obstetrics, gynecology, and reproductive biology·2026
Same author

Robot-assisted, Laparoscopic and Transvaginal Surgery for Pelvic Organ Prolapse: a Comparative Retrospective Single-Center Study.

International urogynecology journal·2026
Same author

Laparoscopic Versus Robot-Assisted Sacrocolpopexy: A Systematic Review and Meta-Analysis.

BJOG : an international journal of obstetrics and gynaecology·2026

相关实验视频

Updated: Jul 7, 2025

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

2.5K

聚焦复合生物相同激素的关注点

Giusi Santangelo1,2,3, Antonio Simone Lagana4, Andrea Giannini1

  • 1Department of Gynecological, Obstetrical and Urological Sciences, "Sapienza" University of Rome, Policlinico Umberto I, Rome, Italy.

Gynecologic and obstetric investigation
|December 27, 2023
PubMed
概括

复合生物相同激素疗法 (CBHT) 提供个性化更年期治疗选择. 需要进一步的研究才能充分理解CBHT.

关键词:
生物相同激素是一种生物相同的激素.雌激素是一种雌激素.激素替代疗法是一种激素替代疗法.更年期的症状 更年期的症状在绝经后的绝经后,孕激素是前性激素的一种.

更多相关视频

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model
05:32

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model

Published on: August 11, 2023

1.8K
Author Spotlight: Investigating Islet Abnormalities and Function with a Pseudoislet Protocol
08:04

Author Spotlight: Investigating Islet Abnormalities and Function with a Pseudoislet Protocol

Published on: November 3, 2023

2.0K

相关实验视频

Last Updated: Jul 7, 2025

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

2.5K
Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model
05:32

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model

Published on: August 11, 2023

1.8K
Author Spotlight: Investigating Islet Abnormalities and Function with a Pseudoislet Protocol
08:04

Author Spotlight: Investigating Islet Abnormalities and Function with a Pseudoislet Protocol

Published on: November 3, 2023

2.0K

科学领域:

  • 生殖内分泌学和妇女健康.
  • 药理学和制药科学.
  • 基于证据的医学.

背景情况:

  • 对于更年期的激素替代疗法 (HRT) 的使用是有争议的,部分原因是女性健康倡议 (WHI) 研究的提前终止.
  • 医生对HRT表达了持续的担忧,引发了对替代治疗方法的兴趣.
  • 对个性化医疗的需求导致复合类固醇激素制剂的使用增加.

研究的目的:

  • 评估临床效用和当前支持复合生物相同激素治疗 (CBHT) 的证据.
  • 评估个性化类固醇激素制剂作为传统HRT的替代品的潜力.
  • 确定将CBHT纳入临床实践所需的步骤.

主要方法:

  • 在2023年6月,在主要数据库 (MEDLINE,Embase,PubMed,Cochrane) 进行了广泛的文献搜索.
  • 符合预定义的纳入和排除标准的研究被选中进行分析.
  • 进行了数据提取和分析,并通过共识解决了差异.

主要成果:

  • 审查的重点是复合生物相同激素 (CBHT) 的临床实用性.
  • 目前的证据表明,提高知识和意识对于考虑CBHT至关重要.
  • 主要结果表明需要进一步调查CBHT的疗效和安全性.

结论:

  • 复合生物相同激素配方可能为个别患者提供量身定制的治疗选择.
  • 进一步的研究和教育对于确定CBHT在临床实践中的作用至关重要.
  • 个性化类固醇激素制剂代表了更年期症状管理的不断增长的领域.