口水对抗阿西克洛维尔抗性简单疹病毒的杀菌作用
M Bar Ilan1,2, S Dovrat3, R Cohen3
1Oral Medicine Unit, Sheba Medical Center, Tel-Hashomer, Israel.
Oral diseases
|December 27, 2023
概括
在商业上可用的口水显示抗病毒活性对抗抗酸克洛维尔的简单疹病毒1型 (HSV-1) in vitro. 精油和波维-口水是最有效的,这表明在免疫受损患者中管理HSV-1感染的潜力.
科学领域:
- 病毒学 病毒学
- 口腔医学是指口腔医学.
- 传染性疾病 传染性疾病
背景情况:
- 简单疹病毒1型 (HSV-1) 感染在免疫功能低下的人中可能是严重的.
- 由于长期的抗病毒治疗,经常出现抗环 (ACV) 的HSV-1菌株.
- 管理这些耐药菌株是一个临床挑战.
研究的目的:
- 为了评估常见的口服水对抗抗氧化克洛维尔耐药的HSV-1菌株的杀毒效果.
- 为了比较不同口水配方的有效性.
主要方法:
- 测试了两种抗阿西克洛维尔的HSV-1菌株.
- 暴露于以精油为基础的基酸和povidone-iodine口水30秒.
- 病毒传染性通过减少斑块的测试来评估.
主要成果:
- 所有测试的口水在体外显著降低了HSV-1感染力.
- 基于精油和povidone-iodine的口腔洗剂的疗效略高于.
- 测试的口腔冲洗在体外表现出对抗ACV耐药性HSV的抗病毒活性.
结论:
- 商业上可用的口水具有体外抗病毒特性,可以对抗抗克洛维尔耐药的HSV.
- 需要进行进一步的临床试验,以确认这些冲洗在减少免疫受损患者口腔HSV病变方面的有效性.
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