柴胡 - 舒甘 - 桑对功能性消化不良和肠道微生物群的影响:一项随机,双盲,安慰剂对照试验
Yujiao Wang1, Yuebo Jia1, Xuejiao Liu1
1Department of Gastroenterology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Journal of ethnopharmacology
|December 27, 2023
概括
柴胡-舒甘-桑 (CSS) 通过改善症状和肠道微生物群,有效治疗功能性消化不良 (FD). 这种传统中医药还可以减少FD患者的焦虑和抑郁.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 传统中国医药 传统中国医药
背景情况:
- 柴胡-舒甘-桑 (CSS) 是一种传统的中医药配方,历史上用于胃肠道疾病.
- 功能性消化不良 (FD) 是一种普遍的疾病,目前支持当前治疗的高质量证据有限.
- 需要随机,双盲,安慰剂对照试验来验证CSS对FD的疗效.
研究的目的:
- 与安慰剂相比,评估CSS在功能性消化不良 (FD) 的治疗疗效.
- 研究CSS对FD患者肠道微生物群组成的影响.
主要方法:
- 一个随机,双盲,安慰剂对照试验,涉及94名参与者,符合Rome IV标准的FD.
- 用CSS或安慰剂进行干预四周,主要结局是症状得分 (SDS).
- 二次结局包括胃排空,焦虑,抑郁,生活质量,以及肠道微生物群的16SrRNA测序.
主要成果:
- 与安慰剂相比,CSS显著改善了消化不良症状得分 (SDS) (P < 0.001).
- 治疗CSS导致胃排空率,焦虑 (HAMA),抑郁 (HAMD) 和生活质量 (FDDQL) 评分显著改善.
- 16S rRNA测序显示,FD患者的肠道微生物群多样性和丰度发生了变化,CSS调节了特定的细菌群.
结论:
- 在治疗功能性消化不良 (FD) 方面,Chaihu-Shugan-San (CSS) 显示出比安慰剂更高的疗效.
- 在FD患者中,CSS对胃排空,焦虑和抑郁有积极的影响.
- 在患有FD的个体中,CSS治疗会影响肠道细菌社区结构.
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