主要心脏大B细胞淋巴瘤
Sumukh Arun Kumar1, Rahul Mishra2, Sarat Chandra Malempati3
1Internal Medicine, Saint Vincent Hospital, Worcester, Massachusetts, USA sumukharunkumar95@gmail.com.
BMJ case reports
|December 27, 2023
概括
一个罕见的初级心脏大B细胞淋巴瘤与MYC和BCL6重组的病例被诊断为女性. 患者实现了化学疗法的完整反应,尽管由于缺少CD20表达而中止Rituximab.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 心脏病学 心脏病学
背景情况:
- 初级心脏淋巴瘤是一种罕见的恶性瘤.
- 早期诊断和准确的表征对于有效的治疗至关重要.
研究的目的:
- 报告一例原发性心脏大B细胞淋巴瘤,MYC和BCL6重组的病例.
- 讨论诊断挑战和治疗结果.
主要方法:
- 诊断工作包括成像 (CT胸部),心周液分析 (细胞学,流动细胞计),免疫组织化学和细胞遗传学 (FISH).
- 患者接受了剂量调整的埃托波西德,普雷迪尼松,温克里斯,环胺,多克索鲁比辛和修复剂 (DA-EPOCH-R) 化疗.
- 响应评估使用临时正子辐射断层扫描-CT.进行.
主要成果:
- 周心液分析显示不典型的淋巴细胞对B细胞标志物 (CD79a,CD10,PAX-5,BCL-2,BCL6) 呈阳性.
- 细胞遗传学测试显示MYC和BCL6的重组.
- 患者在三轮化疗后实现了完全反应,并完成了六轮化疗,尽管由于缺少CD20表达而停止服用Rituximab.
结论:
- 主要心脏大B细胞淋巴瘤与MYC和BCL6重组是一个不同的实体.
- 多模式诊断工作对于准确的诊断至关重要.
- DA-EPOCH-R化疗可能是有效的,即使CD20表达变化.
相关概念视频
Cells of the Adaptive Immune Response
990
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
990
B Cell Activation and Differentiation
1.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.7K
Primary Lymphoid Organs
1.6K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
1.6K


