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Author Spotlight: A New and Efficient Method for Comprehensive Metabolite Cytotoxicity Assessment of Triazole Pesticides in Plants
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植物导致有毒肌肉病变

Beatrice Sponseller1, Tim Evans2

  • 1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, 1809 South Riverside Drive, Ames, IA 50011, USA.

The Veterinary clinics of North America. Equine practice
|December 27, 2023
PubMed
概括
此摘要是机器生成的。

某些树木,如盒子树和树,含有毒素,导致马的季节性牧场肌肉病 (SPM) 或非典型肌肉病 (AM). 这些毒素抑制能量代谢,甚至在花草中,也可能是致命的.

关键词:
青素基子是什么 青素基子盒子树和松树树.心肌病是一种心肌病.低糖素A是一种低糖素.没有光线的金棍.毒性肌肉病症是一种毒性肌肉病症.特雷梅托尔/特雷梅顿是一种白蛇的根就是白蛇的根.

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科学领域:

  • 兽医毒理学 兽医毒理学
  • 马类医学 马类医学
  • 植物毒理学 植物毒理学

背景情况:

  • 季节性牧场肌肉病变 (SPM) 和非典型肌肉病变 (AM) 是马中经常致命的有毒肌肉病变.
  • 盒子和松树含有低糖素A (HGA),而白色蛇根和无线金杆含有酸基 (BFK).
  • 已知这些毒素会抑制细胞能量代谢,特别是脂肪酸β-氧化.

研究的目的:

  • 为了识别和表征导致马中SPM和AM的毒素.
  • 了解这些植物毒素引起肌肉病的机制.
  • 为这些有毒肌肉病的预防策略提供信息.

主要方法:

  • 从受影响马放牧的牧场取植物样本进行分析.
  • 毒理学研究以识别和量化诸如HGA和BFK等致病原体.
  • 研究这些毒素影响的代谢途径,包括脂肪酸β-氧化.

主要成果:

  • 来自boxelder和sycamore的低糖素A (HGA) 被证实是SPM/AM的原因,其代谢物MCPA-CoA抑制脂肪酸β-氧化.
  • 来自白蛇根和无光金杆的多重福基 (BFK) 被确定为细胞能量代谢的抑制剂.
  • 发现毒素在花草中保持活跃,可以在马的牛奶中分泌.

结论:

  • 植物性毒素,包括HGA和BFK,是马中SPM和AM的致病原体.
  • 抑制细胞能量代谢,特别是脂肪酸β-氧化,是毒性的主要机制.
  • 风险因素包括在秋季放牧稀疏的牧场,毒素甚至在保存的料和牛奶中构成风险.