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在2型糖尿病门诊护理中的心上脂肪厚度
Gianluca Iacobellis1, Jeffrey J Goldberger2, Alexis E Malavazos3
1Division of Endocrinology, Diabetes and Metabolism, University of Miami, Miami, FL, USA.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|December 27, 2023
概括
用超声波测量的心上脂肪 (EAT) 厚度是2型糖尿病 (T2DM) 患者冠状动脉疾病 (CAD) 的强有力的指标. 这种测量比传统的风险因素更有效,用于预测该人口中的CAD.
科学领域:
- 心脏病学 心脏病学
- 糖尿病学 糖尿病学
- 医疗成像医学成像
背景情况:
- 内脏脂肪,包括心上脂肪 (EAT),与2型糖尿病 (T2DM) 的心血管风险有关.
- EAT在冠状动脉疾病 (CAD) 中起作用,可以通过超声波测量.
- 在T2DM患者的常规门诊中,评估EAT厚度并不常见.
研究的目的:
- 评估出行超声波测量EAT厚度和CAD之间的关联.
- 评估EAT在无症状,得到良好控制的T2DM患者接受甲胺单疗中的预测能力.
主要方法:
- 一个单一中心的实用研究,涉及142名T2DM患者.
- 基线测量包括超声波 EAT 厚度,人体测量和生物标志物.
- 对CAD发病率进行了跟踪,对基线后1年的评估进行了跟踪.
主要成果:
- 基线特征:HbA1c 6.7%,BMI 34.9 kg/m2,EAT厚度 8.3 ± 2.3 毫米 (女性) 和 9.4 ± 2.4 毫米 (男性).
- EAT厚度值超过了高心血管风险的门值.
- 在多变量分析中,EAT厚度是1年CAD发病率 (p=0.04) 的唯一显著相关值.
结论:
- 在照顾点的超声波测量EAT厚度与在T2DM患者中接受甲福林治疗的CAD相关性很好.
- 与传统风险因素 (如BMI,HbA1c,年龄,血压和糖尿病持续时间) 相比,EAT厚度显示出对CAD的优越预测.
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