探索与代谢功能障碍相关的脂肪性肝病患者的职业毒素暴露:一项前性试点研究
Francesco Tovoli1, Bernardo Stefanini2, Daniele Mandrioli3
1Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Division of Internal Medicine, Hepatobiliary and Immunoallergic Diseases, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
概括
患有代谢功能障碍相关的脂肪性肝病 (MASLD) 并发症的工人报告了更高的职业毒素暴露. 长期暴露显著增加了晚期慢性肝病 (ACLD) 和肝细胞癌 (HCC) 的风险.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 职业健康 职业健康 职业健康
- 环境医学 环境医学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 与胰岛素抵抗和肥胖有关,但越来越多的环境污染物被认为是贡献者.
- 了解污染物在MASLD向晚期慢性肝病 (ACLD) 和肝细胞癌 (HCC) 的进展中的作用对于公共卫生至关重要.
- 职业接触有毒物质提供了一个独特的模型来研究环境因素对肝脏疾病的危险影响.
研究的目的:
- 确定在被诊断为MASLD的患者中自我报告的职业毒素暴露的流行率.
- 调查职业暴露与MASLD并发症 (包括ACLD和HCC) 的发展之间的关联.
主要方法:
- 进行了一项前性试点研究,涉及201名MASLD患者.
- 通过使用结构化调查问卷,系统地收集工作场所暴露于有毒物质的数据.
- 患有ACLD/HCC的患者 (n=55) 与使用后勤回归和倾向得分模型的对照组 (n=146) 相比较.
主要成果:
- 与对照组相比,患有ACLD/HCC的患者报告了对金属,制冷剂,疼痛/树脂和燃料排放的更高暴露.
- 在对混因素进行调整后,21-30年 (OR:2.31) 和>30年 (OR:4.47) 的职业接触有毒物质与ACLD/HCC有显著的关联.
- 这些发现突显了长时间的职业毒素暴露与严重肝病结果之间的潜在联系.
结论:
- 在这项试点研究中,患有ACLD/HCC等并发症的MASLD患者更有可能报告在工作场所接触有毒物质.
- 结果表明,职业中毒物质暴露和MASLD进展之间存在显著的关联.
- 需要进一步的多中心研究来证实这些发现,并为处于风险的工人群体的预防策略提供信息.
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