针对针对肝脏以外的器官的非病毒载体的策略
Jeonghwan Kim1,2, Yulia Eygeris1, Renee C Ryals3
1Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Portland, OR, USA.
Nature nanotechnology
|December 27, 2023
概括
纳米粒子有效地提供核酸,但通常会在肝脏中积累. 克服这种肝脏热带性对于开发针对其他器官的纳米药物和扩大治疗应用至关重要.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 纳米颗粒越来越多地用于核酸输送,由于优化性质和内体逃生,在纳米医学中显示出希望.
- 目前非病毒性核酸输送的临床应用主要局限于肝脏疾病和疫苗,由于纳米颗粒在肝脏中的积累 (肝脏热流症).
研究的目的:
- 为了应对非病毒纳米粒子输送系统中肝脏热流症的挑战.
- 探索针对肝脏以外的器官的策略,扩大纳米药物的治疗潜力.
- 为了促进非肝疗法的发现,使用先进的纳米粒子输送.
主要方法:
- 在非病毒载体中对肝脏热的潜在原因的审查.
- 概述各种器官中的解剖结构,生理过程和生物障碍.
- 识别和讨论方法,以实现对非肝脏组织的有针对性的输送.
主要成果:
- 肝脏积累 (热) 是一个重要的障碍,限制了非病毒核酸输送系统的临床使用.
- 了解器官特异性解剖学和生理学是设计纳米粒子用于非肝脏向的关键.
- 存在各种策略来克服肝脏的热带性并使其能够传递给其他器官.
结论:
- 克服纳米粒子肝脏热带性对于开发用于更广泛疾病的纳米药物至关重要.
- 根据器官特异性特征量身定制纳米粒子特征可以打开新的治疗途径.
- 通过对纳米粒子设计和向的战略方法,可以实现非肝性纳米疗法的加速发现.
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