在过敏性犀牛结膜炎的单敏和多敏成年人中服用语言下免疫疗法片
Harold S Nelson1, David I Bernstein2, Tilo Biedermann3
1From the Department of Medicine, National Jewish Health, Denver, Colorado.
Allergy and asthma proceedings
|December 27, 2023
概括
单种过敏原语言下免疫疗法 (SLIT) 药片有效治疗成年人的过敏性鼻炎/结膜炎 (AR/C),无论他们是否对单种或多种过敏原敏感. 这种治疗在多敏感患者中为向过敏原提供了临床益处.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 临床试验 临床试验
- 药物治疗 药物治疗
背景情况:
- 许多患有过敏性鼻炎/结膜炎 (AR/C) 的患者对多种过敏原表现出敏感性.
- 单个过敏原免疫疗法的有效性在多敏感的个体仍然是一个关键的临床问题.
研究的目的:
- 评估下舌免疫疗法 (SLIT) 药片对草,杂草,树木和家尘虫 (HDM) 过敏原的疗效和安全性.
- 为了评估这些SLIT片在AR/C的成年人中,他们要么是单敏化,要么是多敏化.
主要方法:
- 从III期双盲,安慰剂控制的实地试验中对AR/C.患者的成年人 (≥18岁) 的数据进行后期分析.
- 使用季节性过敏原 (草,杂草,树) 的总结合得分 (TCS) 和HDM的总结合鼻炎得分 (TCRS) 来测量有效性,将SLIT片与安慰剂进行比较.
- 在单敏和多敏患者组之间比较了安全性概况.
主要成果:
- 在单敏和多敏成年人中,SLIT药片对草,洋草,树木和HDM过敏原的TCS/TCRS显著改善.
- 例如,草SLIT在两组中都显示出20%的TCS改善;拉格维斯SLIT在单敏感体中显示出19%的改善,在多敏感体中显示出27%的改善.
- 树SLIT在单敏感体中显示了54%的TCS改善,在多敏感体中显示了34%的TCS改善;HDMSLIT在单敏感体中显示了20%的TCRS改善,在多敏感体中显示了17%的TCRS改善. 在各组中,安全概况是可比的.
结论:
- 针对草,杂草,树木或HDM过敏原的语言下免疫疗法 (SLIT) 药片在AR/C的成年人中是有效的,不管他们的敏感状态 (单或多敏感).
- 用SLIT药片针对单个相关过敏原有效地诱导该特定过敏原的临床益处,即使在多重敏感性患者中也是如此.
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