在使用酒精的青少年中对三种药物坚持结果进行对对比
Anna E Kirkland1, Rachel L Tomko1, ReJoyce Green1
1Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
Alcohol, clinical & experimental research
|December 28, 2023
概括
在患有物质使用障碍 (SUD) 的青少年中评估药物坚持是至关重要的. 药丸计数和MEMS显示出良好的一致性,而药物视频在青少年SUD试验中跟踪遵守时不太可靠.
科学领域:
- 临床药理学 临床药理学
- 青少年医学 青少年医学
- 药物使用障碍研究 药物使用障碍研究
背景情况:
- 准确的药物坚持性评估对于理解青少年物质使用障碍 (SUD) 临床试验中的药物治疗结果至关重要.
- 通常使用非生物方法,但它们的一致性需要评估.
- 这项研究侧重于青少年的酒精使用,以告知未来的试验设计.
研究的目的:
- 描述和评估三种常见的非生物药物依从性评估方法之间的对对一致性.
- 为了评估这些方法在青少年使用酒精.
- 为未来青少年SUD试验的坚持措施的选择提供信息.
主要方法:
- 一个随机交叉设计与32名青少年 (17-19岁) 接受N-乙半氨酸和安慰剂10天.
- 通过药物计数,每天两次的药物视频和药物事件监测系统 (MEMS®) 评估药物坚持.
- 林的一致性相关系数 (CCC) 和布兰德-阿尔特曼图分析了一致性;线性混合效应模型也被使用.
主要成果:
- 药丸计数产生了最高的 (89%) 和药物视频最低的 (64%) 坚持估计.
- 观察到方法之间的对应性很差,除了药丸计数和MEMS.
- 布兰德-阿尔特曼图表显示了所有方法的良好配对一致性;交叉中第二种药物的坚持率较低.
结论:
- 使用多种坚持评估方法可以帮助捕获坚持估计,特别是在远程或混合试验缺乏生物标记.
- 评估方法的选择应与具体的研究目标保持一致.
- 在临床试验中严格评估药物治疗时,对药物坚持的持续研究至关重要.
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